Laboratory of Physics of Nanostructured Biocomposites

Brief historical background about the unit

The laboratory was created on January 14, 2003, consisting of 5 people, including 2 candidates of science. The first name of the laboratory is “Interdepartmental Laboratory of Biocompatible Implants and Coatings.” In May 2006, during the reorganization of the Institute’s structure, a group of employees from the Laboratory of Gas-Thermal Coatings joined the laboratory. At the same time, the laboratory received a new name “Laboratory of Physics of Nanostructured Biocomposites”.

About the field of research, directions of fundamental research

1. Structure and properties of nanostructured and ultrafine-grained metal materials, including bioinert metals: titanium, zirconium, niobium, and alloys based on them, methods of severe plastic deformation for obtaining bulk ultrafine-grained and nanostructured metal materials.

2. Methods for producing bio-coatings based on calcium phosphates: micro-arc (microplasma) oxidation / plasma-electrolytic oxidation, high-frequency magnetron sputtering, structure and properties of bio-coatings.

3. Structure and properties of biocomposites based on nanostructured and ultrafine-grained alloys based on titanium, zirconium and niobium, oxide, calcium-phosphate and silicate-phosphate biocoatings for dental implantology, traumatology and orthopedics, maxillofacial surgery, etc.

4. Development of implants for various medical applications.

5. Development of additive technology methods, including the method of selective laser melting, to produce alloys with a low elastic modulus based on the titanium-niobium system.

6. Physics of interaction of flows of charged particles with metals and alloys.

7. Physics of strength and ductility of metals, alloys and steels.

8. Nonequilibrium structural-phase transformations in metals and alloys initiated in local areas of metals and alloys during electron beam and laser selective alloying.

Problems solved within these areas

1. Development of a method of severe plastic deformation to create bioinert alloys based on titanium, zirconium and niobium in an ultra-fine-grained state with a low elastic modulus and a high level of strength characteristics, ensuring high biomechanical compatibility of the “bone tissue-implant” system. Control of processes of severe plastic deformation to ensure reproducible structural and physical-mechanical characteristics of cast binary and multicomponent bioinert alloys based on titanium, niobium, zirconium in an ultra-fine-grained and nanostructured state.

2. Study of the patterns of formation of microstructure and mechanical properties, structural-phase transformations of bioinert alloys based on titanium, zirconium and niobium as a result of severe plastic deformation, study of the relationship between the parameters of the structural-phase state and mechanical characteristics.

3. Control of the processes of RF magnetron and microarc deposition of bio-coatings-scaffolds on the surface of bioinert alloys, providing a pronounced surface topography in accordance with the “niche-relief” concept, carrying antibacterial and osteotropic microelements, medicines, cellular material.

4. Optimization of the choice of methods of physical influence in the process of applying biocoatings to alloys with different phase and elemental compositions, surface topography, ensuring the creation of modified surface-charged RF magnetron and microarc biocoatings.

5. Identification and diagnostics of the mechanical properties of nanostructured bioinert alloys based on detection by infrared thermography methods and correlation of digital images of temperature fields and displacement fields.

6. Development of implants for various medical applications from biocomposites based on nanostructured and ultrafine-grained alloys, including those with a low elastic modulus, and calcium phosphate bio-coatings.

Unit composition

The total number of people is 16, including:
doctors of science - 3,
candidates of science - 8,
young researchers (up to 39 years old) - 6
graduate students - 3.

List of staff members

Sharkeev Yuri Petrovich - senior researcher, head. Lab., Doctor of Physics and Mathematics , sharkeev@ispms.ru
Legostaeva Elena Viktorovna - senior researcher, doctor of technical sciences, lego@ispms.ru
Sedelnikova Maria Borisovna - senior researcher, doctor of technical sciences, smasha5@yandex .ru
Eroshenko Anna Yuryevna - senior researcher, candidate of technical sciences, eroshenko@ispms.ru
Lastovka Vladimir Viktorovich - lead. technologist, Ph.D., vladimirlastovka1948@gmail.com
Nazarenko Nelly Nikolaevna - researcher, Ph.D. , nnelli@ispms.ru
Komarova Ekaterina Gennadievna - researcher, Ph.D., katerina@ispms.ru
Popova Ksenia Sergeevna - junior researcher, Ph.D. , kseniya@ispms.ru
Tolmachev Alexey Ivanovich - chief. specialist, tolmach@ispms.ru
Uvarkin Pavel Viktorovich - lead. technologist, uvarkin@ispms.ru
Tolkacheva Tatyana Viktorovna - lead. technologist, tolkacheva@ispms.ru
Glukhov Ivan Aleksandrovich - lead. technologist, gia@ispms.ru
Luginin Nikita Andreevich - laboratory research assistant, TPU graduate student, nikishek90@gmail.com
Kashin Alexander Daniilovich - graduate student, sapiunt1@yandex.ru
Ugodchikova Anna Vladimirovna - applicant, ugodch99@gmail.com
Khimich Margarita Andreevna - k Technical Sciences, Junior Researcher LNBI, khimich@ispms.ru
Chebodaeva Valentina Vadimovna - Ph.D., junior researcher LNBI, vtina4@mail.ru
Prosolov Konstantin Aleksandrovich - junior researcher LNBI, konstprosolov@gmail.com
Kazantseva Ekaterina Aleksandrovna - junior researcher, graduate student of TSU, LNMMMS, kati10_95@mail.ru

The most important scientific results

1. Biocomposites based on titanium and its alloys in nanostructured and ultrafine-grained states and calcium phosphate biocoatings with a heterogeneous structure have been developed and studied. A microarc oxidation technology has been developed that allows the formation of calcium phosphate coatings on substrates made of bioinert alloys (Ti, Nb, Zr, Mg, etc.) with a wide range of physicochemical properties, varying degrees of crystallinity, thickness, roughness and porosity. The influence of the electrophysical parameters of microarc deposition on the properties of coatings: thickness, size of spherulites and pores, and adhesive strength of coatings was studied. It has been shown that with increasing pulse duration in the anodic mode, a linear increase in coating parameters occurs: thickness, dimensions of structural elements with a consistently high level of adhesive strength. At the same time, reducing the duration and frequency of pulses and adding cathode current causes a decrease in adhesive strength, which is associated with an increase in the overall porosity of the coatings. A phenomenological model of the formation of a calcium phosphate coating in microarc discharges on the surface of titanium and zirconium doped with niobium is proposed, which makes it possible to explain the reason for the different structural-phase state and physical and mechanical properties of coatings formed on different substrates. It has been shown that coatings on the surface of titanium are in an X-ray amorphous state and have higher adhesive strength to the substrate compared to nanocrystalline coatings on the surface of zirconium containing CaZr ₄ (PO ₄ ) ₆ , ОІ-Ca ₂ P ₂ O ₇ , ZrP ₂ O ₇ , ZrO ₂ , due to different phase composition (the presence of ОІ-Nb particles in the zirconium alloy) and electrical characteristics of metal substrates, as well as passivating oxide films on their surface (TiO ₂ , ZrO ₂ and Nb ₂ O ₅ ).

2. A number of electrolyte compositions have been developed to create, by microarc oxidation, new types of hydrophilic antibacterial calcium phosphate biocoatings modified with the elements Zn, Cu, La, Si and Ag, as well as composite wollastonite-calcium phosphate coatings on titanium and titanium-niobium alloy (Ti-40Nb) in ultrafine-grained state. The incorporation of Zn ²⁺ , Cu ²⁺ , La ³⁺ and SiO ₄ ^{4- ions into the composition of biocoatings leads to the formation of nanocrystalline phases ОІ-Ca} ₂ P ₂ O ₇ , CaHPO ₄ , TiO ₂ (anatase) and Nb ₂ O ₅ in the coatings with crystallite sizes of 5-80 nm. Ag-containing coatings on titanium and Ti-40Nb alloy have a submicrocrystalline microstructure with crystallite sizes up to 200 nm and contain crystalline phases: hydroxyapatite, О±-Ca ₃ (PO ₄ ) ₂ , ОІ-Ca ₃ (PO ₄ ) ₂ , TiO ₂ ( anatase and rutile), Nb ₂ O ₅ . A pulse voltage range of 150-250 V has been established, which ensures the formation of Zn-, Cu-, La-, Si- and wollastonite-containing calcium phosphate coatings with an optimal set of properties on the surface of titanium and Ti-40Nb alloy: 25-55 Вµm thick, 2- 5 microns, porosity 15-25%, and adhesive strength - 20 В± 4 MPa.

3. Modification of the surface of biocoatings based on calcium phosphates with positively charged boehmite nanoparticles AlO(OH) helps to increase the hydrophilic properties of the coatings, increasing the surface energy to 110 mN/m and the zeta potential to -23В±3 mV. The presence of areas with positively charged boehmite particles on the surface of biocoatings makes it possible to change the zeta potential of the coating surface and selectively vary their adhesive properties towards cells, proteins and bacteria.

4. Micro-arc protective calcium phosphate coatings deposited on a bioresorbable magnesium alloy were studied by varying the pulse voltage of micro-arc oxidation in the range of 350-500 V. Polyphase composition of the coatings, including ОІ-Ca ₃ (PO ₄ ) ₂ , О±-Ca ₃ (PO ₄ ) ₂ , hydroxyapatite and MgO, provides a 10-fold reduction in the rate of bioresorption of magnesium alloy and stimulates osseointegration processes.

5. It has been shown that calcium phosphate coatings (X-ray amorphous, nanocrystalline based on non-stoichiometric calcium phosphates, ОІ-tricalcium phosphate and/or hydroxyapatite), obtained by the microarc method on bioinert alloys of titanium, zirconium and niobium, are biocompatible, promote osseointegration with bone tissue and can be used as biocoatings on implants for various purposes. Surface roughness is a determining factor for bone tissue bioengineering compared with phase composition, crystallinity, porosity, pore size and Ca/P ratio. The experimentally established optimal range of roughness of calcium phosphate coatings, equal to Ra 2-3 Ојm, promotes osteogenic differentiation of mesenchymal multipotent human stromal stem cells 20-50 Ојm in size in vitro and acceleration of bone tissue in the ectopic bone formation test in vivo.

6. Modification of the surface of titanium implants with a hydroxyapatite-based coating applied by RF magnetron sputtering contributes to a significant increase in the electrical potential of the surface. A higher surface potential accelerates the adhesion of proteins to the implant surface. This in turn induces increased adhesion of osteoblasts to the surface.

7. The dynamics of the decomposition process of a particle in an electric field has been theoretically studied, taking into account heat and mass transfer between the particle and the surrounding liquid phase. The distribution of temperature and concentration in the particle and in the surrounding liquid is influenced by the power of the heat source associated with the action of the electric field, the compressibility coefficient, the reaction rate constant and the proportion of natural phosphate particles. It was found that the tangential stresses in the particle change sign, which may be the reason for the destruction of particles under microarc oxidation conditions.

8. A model for the growth of a calcium phosphate coating was studied numerically, taking into account non-ideal contact. It has been shown that an increase in the roughness of the substrate leads to an increase in the concentration of calcium, phosphate and calcium pyrophosphate and a decrease in other concentrations in the vicinity of the interface. It was revealed that the gap in concentrations at the interface leads to an increase in some concentrations (titanium oxide and titanium pyrophosphate) and a decrease in others (calcium, phosphate and calcium pyrophosphate).

9. A model for the growth of a calcium phosphate coating on a zirconium substrate was formulated and studied, taking into account the formed oxide sublayer. An increase in the reaction rate constant leads to an increase in the substances formed in the coating. Variation in the fraction of particles in the electrolyte affects only the phosphate and calcium-zirconium phosphate, as well as the voltages in the vicinity of the oxide layer. In the coating, the stresses transform from compressive to tensile; in the vicinity of the oxide layer/coating boundary, the stresses increase in magnitude with an increase in reaction rate constants and the proportion of hydroxyapatite particles or a decrease in the process stress and diffusion coefficient in the coating. The stresses in the vicinity of the substrate/oxide layer interface are greater in the presence of an oxide layer than in the absence of it.

10. A team of authors from the laboratory proposed a method for forming coatings on implants from bioinert materials, which consists of sputtering a target containing hydroxyapatite Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ in a high-frequency (RF) discharge plasma [RF Patent 2476243]. This method made it possible to obtain calcium phosphate biocoatings with high physical and mechanical properties both on the surface of titanium and its alloys, as well as on ceramic samples. The RF magnetron sputtering installation is an automated complex of vacuum ion-plasma equipment with programmable operating modes. The design of the installation provides the following processing modes: coating deposition and ion cleaning of sample surfaces. The working gas injection system contains two channels (argon and oxygen).

11. During the period 2013-2017. the Laboratory team was part of the international consortium under the 7th European Framework Program, competition FP7-PEOPLE-2013-IRSES, project No. 612691 “International community on new strategies for the production of calcium phosphates.” During the work on the project, biphasic ceramic targets were synthesized based on homogeneous mixtures of tricalcium phosphate and hydroxyapatite powders of various concentrations. Based on the results of the project, the relationship between the size of the structural elements of the coating and the type of sputtering target was experimentally established and a mechanism was found by which it is possible to control the size of the structural elements of the coating. The fundamental dependences of the influence of external physical conditions (such as forced heating and displacement potential), as well as the composition of targets on the formation of thin-film calcium phosphate coatings, have been established.

12. A comprehensive cycle of work devoted to the formation of antibacterial coatings based on zinc-substituted hydroxyapatite (Zn-HAP) was completed. Thus, antibacterial RF magnetron coatings in amorphous, amorphous-crystalline and crystalline states were formed on ultrafine-grained titanium of the VT1-0 grade and on titanium in the as-delivered state. Studies were carried out on the structure of the coatings and their biological properties. It has been shown that the use of ultrafine-grained titanium is considered appropriate for the formation of crystalline Zn-HAP coating. To control the degree of crystallinity, it is also possible to use forced heating of samples during RF magnetron deposition. Biological tests of such coatings showed the absence of a toxic effect and the presence of bacteriostatic properties.

13. A process has been developed for manufacturing calcium phosphate targets of a given shape for RF magnetron sputtering. There is experience in the synthesis of solid ceramic targets from calcium phosphate powders of various compositions. Today, the magnetron sputtering system is equipped with replaceable targets of various compositions: 100% HAP, 100% TCP, 50% HAP/50% TCP, Ag-HAP, Zn-HAP, Cu-HAP. Currently, modes for the formation of calcium phosphate coatings with specified properties have been developed.

14. The RF magnetron sputtering method is used to apply calcium phosphate bio-coatings on the surfaces of ceramics and bioinert alloys of titanium, zirconium and low-modulus alloy of the titanium-niobium system. The structure, composition, mechanical and biological properties of coatings were studied. It has been shown that coatings provide a significant increase in the osseointegration properties of implants made of ceramics and bioinert metals and alloys.

15. Research is currently being actively carried out in the field of the charge state of thin RF magnetron coatings. Modification of the surface of titanium implants with a hydroxyapatite-based coating applied by RF magnetron sputtering contributes to a significant increase in the electrical potential of the surface. A higher surface potential accelerates the adhesion of proteins to the implant surface. Which in turn induces increased adhesion of osteoblasts to the surface.

16. A combined method has been proposed for producing workpieces in the form of rods of nanostructured and ultrafine-grained titanium VT1-0 and ultrafine-grained binary alloys based on titanium, zirconium and niobium - Ti-(40-45) wt. % Nb and Zr-1 wt. % Nb with a homogeneous structure throughout the volume of the workpiece, including multiple uniaxial pressing in a mold with a change in the deformation axis and multi-pass rolling at room temperature, followed by pre-recrystallization annealing. Billets made of nanostructured and ultra-fine-grained titanium are recommended for use in medical practice for the manufacture of implants, including dental implants. Titanium VT1-0 in nanostructured and ultrafine-grained states has high osseointegration properties.

17. Using methods of severe plastic deformation, an ultrafine-grained state (the average size of elements of the grain-subgrain structure is 0.25 Ојm) in a low-modulus bioinert Ti alloy - 40 wt. was obtained and studied. % Nb. The ultrafine grain state provides a significant increase in mechanical properties while maintaining a low elastic modulus comparable to that of bone tissue.

18. It has been established that plastic deformation of bioinert titanium and zirconium in an ultrafine-grained high-strength state occurs localized at the macroscopic level and has an autowave nature. What is common is that the collapse of localized deformation autowaves (pre-fracture stage) develops mainly after the loss of global stability of plastic flow. The fracture of samples of both materials develops in a ductile manner. The location of destruction is determined by the position of a stationary high-amplitude localization source, in which the collapse of the autowave of localized macrodeformation occurs. In the destruction zone, the ultrafine-grained structure of the materials does not undergo significant changes. The resulting ultrafine-grained titanium VT1-0 and zirconium alloy E110 have high structural strength, mechanical and thermal stability, and therefore are promising as materials for the manufacture of medical implants.

19. It has been shown that plastic deformation of metals and alloys from a coarse-crystalline to an ultrafine-grained / nanostructured state changes the deformation behavior of the material under mechanical loading. The search for non-destructive express methods for mechanical assessment of the durability and reliability of products is very relevant. Studies have been carried out of the mechanical behavior of VT1-0 titanium samples in coarse-crystalline and ultrafine-grained states during their uniaxial tension at strain rates of 0.01 and 0.1 s ^-1 with simultaneous recording of their temperature fields using IR thermography. Under the considered loading conditions, the temperature increment in the fracture zone of ultrafine-grained VT1-0 samples is lower on average by 4.37В°C than for samples in the coarse-crystalline state, which indicates the ability of titanium in the ultrafine-grained state to more effectively use the structural channel of energy absorption during its deformation, involving the entire deformed volume in this process.

20. Theoretically, based on a mathematical model of diffusion interaction, the dissolution of a calcium phosphate coating upon interaction with a biological fluid was studied. A model for the dissolution of an individual spherulite is formulated and numerically studied as a submodel in the model for the dissolution of phosphate in a physiological solution. An assessment was made of the time to reach critical stresses leading to the destruction of spherulite. It is shown that the rate of spherulite dissolution and the possible time of its destruction depend on the proximity to the surface and angle of the sample, as well as on the diffusion coefficient and the coefficient of concentration expansion.

21. Ultrasonic treatment has been shown to be a highly effective method of surface modification. A change in the physicochemical and mechanical properties of the surface of a material occurs due to a change in the phase composition, an increase in the concentration of defects in the crystalline structure, the formation of a submicrocrystalline (up to nano-sized) structure and compressive internal stresses. Ultrasonic surface treatment intensifies the process of diffusion saturation of the material surface, increases the depth of the resulting gradient layer, changes the phase ratio, which leads to increased wear resistance of the resulting product. When applying gas-thermal coatings to a surface treated with ultrasound, the formation of a wavy submicrorelief and a modified structure of the surface layer ensures a uniform impact of pulse and pressure pressure of liquid droplets of the sprayed material on the base and promotes the formation of a reliable adhesive bond.

22. The basic models of the flow of non-ideal biological fluids in flat and cylindrical layers, taking into account concentration expansion, compressibility and barodiffusion, have been theoretically studied. It was revealed that the influence of the model parameters is different in the case of convective and diffusion flow regimes. It has been established that taking into account the interrelation of phenomena of various physical natures can play a major role in changing the nature of the flow. The distribution of velocity and concentration for different thicknesses of the cylinder wall differs, which is associated with a change in the ratio of the characteristic scales of diffusion and convection. The influence of the model parameters on the distribution of velocity and concentration at a small thickness of the cylinder layer is qualitatively similar to the flat layer. The barodiffusion effect has the greatest influence in the convective mode and with a small cylinder wall thickness. In the diffusion mode, barodiffusion has virtually no effect and can be ignored.

23. It has been shown that calcium phosphate coatings (X-ray amorphous, nanocrystalline based on doped and non-stoichiometric calcium phosphates, ОІ-TCP and HA), obtained by the microarc method on bioinert alloys of titanium, zirconium and niobium, are biocompatible, promote osseointegration with bone tissue and can be used as biocoatings on implants for various purposes.

24. It has been shown that the introduction of charged aluminum oxyhydroxide and zinc oxide nanoparticles into a microarc electret porous calcium phosphate coating formed on a titanium substrate changes the charge state of the surface by compensating for the negative charge of the original coatings and increases the zeta potential of the coatings. Modification of the surface of calcium phosphate coatings and the internal pore space with positively charged AlO(OH) and ZnO nanoparticles activates the adhesion of cells to the coatings and the antibacterial properties of biocoatings.

Developments

1. Modern designs of dental intraosseous screw implants with instruments and accessories made of nanostructured and submicrocrystalline titanium VT1‑0 with a resorbable calcium phosphate coating have been developed. Nanostructured titanium VT1‑0 has mechanical characteristics comparable to the properties of alloyed titanium alloys used in medicine; it has an advantage over alloyed alloys because it does not contain alloying elements harmful to a living organism, such as aluminum, vanadium, molybdenum. Technical specifications “Set of dental implants made of titanium with tools and accessories”, TU 942422.001-10, a set of design and technological documentation have been developed, protocols for technical, morphological, toxicological, and medical clinical tests of a set of dental implants made of nanostructured titanium have been approved. Registration certificate of the Federal Service for Surveillance in Healthcare and Social Development No. FSR 2011/10619 dated April 25, 2011 was received, the validity period of which is unlimited. The certificate confirms that the medical product “Set of dental implants made of titanium with tools and accessories” according to TU 942422.001-10 is permitted for production, sale and use in the Russian Federation.

2. Installations for applying oxide and calcium phosphate biocoatings on the surfaces of valve metals and alloys using the microarc oxidation method MicroArc - 3.0.

3. Installation for applying thin calcium phosphate bio-coatings on the surfaces of any materials using high-frequency magnetron sputtering methods Yakhont - 2M.

4. Complex for ultrasonic finishing of locomotive wheel set tires.

5. Kit for ultrasonic impact treatment of welded seams.

6. Installation of selective laser melting VARISKAF-100 MVS (LFNB, ISPMS SB RAS, Yurga Technological Institute (branch) TPU).

7. A software and hardware complex has been developed for the early diagnosis of malignant tumors and methods for analyzing the effectiveness of antitumor drugs using laser interference microscopy and infrared thermography (LFNB, LMSPF, Institute of Physics and Mathematics of the Siberian Branch of the Russian Academy of Sciences, PFRC Ural Branch of the Russian Academy of Sciences).

8. Antibacterial coatings have been developed for implants made of titanium and magnesium alloys (LFNB, Institute of Physics of Applied Mathematics SB RAS, LLC NPK SINTEL). The development was applied at NPK SINTEL LLC.

Projects, grants, contracts

Major publications

List of patents

1. Russian Federation patent for invention No. 2291918. Shashkina G.A., Sharkeev Yu.P., Kolobov Yu.R., Karlov A.V. Calcium phosphate coating on titanium and titanium alloys and method of its application, publ. 01/20/2006. Bull. No. 2

2. Russian Federation patent for invention No. 20051262294. Bratchikov A.D., Sharkeev Yu.P., Kolobov Yu.R., Eroshenko A.Yu., Kalashnikov M.P., Method of deformation processing of materials and a device for its implementation, publ. 02/27/2007.

3. RF patent for invention No. 2315117. Bratchikov A.D., Sharkeev Yu.P., Kolobov Yu.R., Eroshenko A.Yu., Kalashnikov M.P. Method of deformation processing of materials and device for its implementation, publ. 01/20/2008. Bull. No. 2.

4. RF patent for utility model No. 71537. Sharkeev Yu.P., Belyavskaya O.A., Polenichkin V.K., Khlusov I.A., Fortuna S.V., Lukonin S.E. Dental implant (options), publ. 03/20/2008. Bull. No. 8.

5. Patent of the Republic of Belarus No. 11777. Kukareko V.A., Bely A.V., Kopylov V.I., Kononov A.G., Sharkeev Yu.P., Eismont O.L. Method for processing biocompatible material made of titanium or zirconium used for medical implant, publ. 01/19/2009.

6. RF patent for invention No. 2008110431. Sharkeev Yu.P., Korobitsyn G.P., Eroshenko A.Yu., Tolmachev A.I., Bratchikov A.D. A method for producing nanostructured bulk material and a device for its implementation, publ. 09/27/2009. Bull. 27.

7. Russian Federation patent for invention No. 2376955. Sharkeev Yu.P., Belyavskaya O.A., Polenichkin V.K., Klimentenko O.P., Fortuna S.V., Polenichkin S.V. Dental intraosseous implant, publ. 12/27/2009. Bull. No. 36.

8. RF patent for invention No. 2383632. Sharkeev Yu.P., Korobitsyn G.P., Eroshenko A.Yu. Tolmachev A.I., Bratchikov A.D. A method for producing hexagonal-shaped workpieces with a nanocrystalline structure and a device for its implementation, publ. 03/10/2010. Bull. No. 7.

9. RF patent for invention No. 2384373. Kolomeets N.P., Lbov A.A., Sharkeev Yu.P., Belyavskaya O.A., Kaminsky P.P., Tolmachev A.I., Naidenkin E.V. , Ratochka I.V., Vinokurov V.A. Ultrasonic oscillatory system, publ. 03/20/2010. Bull. No. 8.

10. RF patent for invention No. 2385740. Legostaeva E.V., Sharkeev Yu.P., Tolkacheva T.V., Tolmachev A.I., Uvarkin P.V. Bioactive coating on a titanium implant and a method for its preparation, publ. 04/10/2010. Bull. No. 10.

11. RF patent for invention No. 2418092. Sharkeev Yu.P., Korobitsyn G.P., Tolmachev A.I., Eroshenko A.Yu., Belyavskaya O.A. A method for producing titanium blanks of multifaceted and round shapes in a nanostructured state and a device for deformation processing of titanium blanks, publ. 05/10/2011. Bull. No. 13.

12. RF patent for invention No. 2436847. Sharkeev Yu.P., Glukhov I.A., Eroshenko A.Yu., Korobitsyn G.P., Tolmachev A.I. A method of deformation to obtain workpieces in a submicrocrystalline and nanostructured state and a device for its implementation, publ. 12/20/2011. Bull. No. 35.

13. RF patent for invention No. 2441621. Sharkeev Yu.P., Polenichkin V.K., Belyavskaya O.A., Polenichkin A.V., Sheshukov S.I. Dental intraosseous implant and abutment for it, publ. 02/10/2012. Bull. No. 4.

14. RF patent for invention No. 2476243. Glushko Yu.A., Kulyashova K.S., Sharkeev Yu.P., Method for obtaining a calcium phosphate coating on an implant from a bioinert material (options), publ. 02/27/2013. Bull. No. 6

15. RF patent for invention No. 134793. Kulkov S.N., Sharkeev Yu.P., Rudensky G.E., Porous ceramic implant for prosthetics of small movable joints, publ. November 27, 2013. Bull. No. 33.

16. RF patent for invention No. 2617572. Sharkeev Yu.P., Saprykin A.A., Kovalevskaya Zh.G., Ibragimov E.A., Babakova E.V., Khimich M.A., Yakovlev V.I., Method for producing composite titanium-niobium powder for additive technologies, publ. 04/25/2017, Bulletin. No. 12. - 3 s.

17. RF patent for invention No. 2612480. Sharkeev Yu.P., Saprykin A.A., Ibragimov E.A., Babakova E.V., Eroshenko A.Yu., Kovalevskaya Zh.G., Khimich M.A., Method for producing low-modulus alloys based on the titanium system -niobium by selective laser melting, publ. 04/25/2017, Bulletin. No. 7. - 5 s.

18. RF patent for invention No. 2623959. Sharkeev Yu.P., Golkovsky M.G., Bataev V.A., Eroshenko A.Yu., Glukhov I.A., Tolmachev A.I., Kovalevskaya Zh.G., A method for producing an alloy from metal powders with a difference melting temperatures, publ. 06/29/2017, Bulletin. No. 19. - 4 s.

19. RF patent for invention No. 2693468. Sharkeev Yu.P., Sedelnikova M.B., Komarova E.G., Chebodaeva V.V., Tolkacheva T.V., Bakina O.V., Method for obtaining a modified biocoating on a titanium implant (options) / Publ. 03/25/2019. Bull. No. 19. - 4 p.

20. RF patent for invention No. 2715055. Prosolov K.A., Sharkeev Yu.P., Lastovka V.V., Bolat-ool A.A., Uvarkin P.V., Khimich M.A., Belyavskaya O.A., Method for obtaining a calcium phosphate coating on a sample / Publ. 02/25/2020. Bull. No. 6. - 12 p.

21. RF patent for invention No. 2745726. Mitrichenko D.V., Prosolov A.B., Komkov A.R., Khlusov I.A., Anisenya I.I., Lastovka V.V., Prosolov K.A., Belyavskaya O.A., Sharkeev Yu .P. A method for producing an antibacterial calcium phosphate coating on an orthopedic implant having the shape of a body of rotation, and equipment for its implementation (options). / patent holder Limited Liability Company “Scientific and Production Company “SINTEL” (RU). - No. 2020117762; appl. 05/29/2020; Publ. 03/31/2021, Bulletin. No. 10. - 16s.

Resources

1. Presses for 1200, 1600, 2500 and 6000 kN, rolling mills with flat and grooved rolls, rollers for producing metal materials in ultra-fine-grained, submicrocrystalline and nanostructured states with high service properties.

2. Two microarc oxidation installations “Microarc-3.0” for applying oxide and calcium phosphate coatings to valve metals and alloys.

3. Vacuum installation for applying thin calcium phosphate bio-coatings using RF magnetron sputtering “Yakhont-2M”.

4. Metallographic microscope Altami MET 1C.

5. Microhardness tester PMT-3M.

6. Profilometer-296.

7. Installation of selective laser melting "VARISKAF-100 MVS"

8. Equipment of the Center for Shared Use "Nanotech" of the Institute of Physics and Mathematics of Applied Mathematics SB RAS and REC TSU (microhardness tester Duramin-5, hardness tester Duramin-500 A75, scanning electron microscope Philips SEM 515, system with electron and focused ion beam Quanta 200 3D, X-ray fluorescence wave-dispersive spectrometer of sequential action XRF- 1800, X-ray diffractometer DRON-7, X-ray diffractometer Shimadzu XRD 6000, laser microscope MIM-340, tribometer "Pin-on-Disc Tribotester", cutting machine Secotom-10, grinding and polishing machine TetgraPol-15+TegraForce-1+TegraDoser- 5, VEM-3SM radial rolling mill, etc.).

Communication with universities

Sharkeev Yu.P. - Research School of Physics of High-Energy Processes, TPU, professor.

Luginin N.A. - TPU graduate student.

Kazantseva E.A. - TSU graduate student

Khimich M.A. - Associate Professor of the Department of Mechanics of Deformable Solids, Faculty of Physics and Technology, TSU; engineer of the Tomsk Materials Science Center for Collective Use of TSU

Public acceptance

Sharkeev Yu. P.

1. Prize named after Academician V.A. Koptyuga (SB RAS-NASB, 2002).
2. Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture in the nomination “Prizes for scientific and scientific-pedagogical workers who have made a significant personal contribution to the development of science and education” in 2007.
3. Letter of gratitude from the Council of Rectors of Universities of the Tomsk Region ( 2017).
4. Anniversary sign “75 years of the Tomsk region, (2019).
5. Certificate of honor from the rector of NI TPU (2020).
6. Certificate of honor from the Administration of the Tomsk Region (2021).

Komarova E.G.

DAAD Fellow under the Leonhard Euler Program of the German Academic Exchange Service (DAAD-202)

Winner of the Prize of the Legislative Duma of the Tomsk Region for young scientists and young talents in the category “Technical Sciences” (2016).

Certificate of honor from the Presidium of the Siberian Branch of the Russian Academy of Sciences (2019).

Chebodaeva V.V.

DAAD Fellow under the Leonhard Euler Program of the German Academic Exchange Service (DAAD - 2015)

Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture for achievements in the field of science, 2020.

Prosolov K.A.

DAAD Fellow under the Leonhard Euler Program of the German Academic Exchange Service (DAAD-2017)

Scholarship holder of the President of the Government of the Russian Federation for students studying abroad for the 2018-2019 academic year

Scholarship from the Government of Italy to conduct research at Italian institutes and research centers in the 2018-2019 academic year.

Khimich M.A.

DAAD Fellow under the Leonhard Euler Program of the German Academic Exchange Service (DAAD-2014)

The laboratory team is a laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture in the nomination “Prizes for scientific and scientific-pedagogical teams” in 2010.

Defense of dissertations

1. Legostaeva Elena Viktorovna, candidate of physical and mathematical sciences. Dissertation “Patterns of formation of gradient micro- and mesostructures during friction and their role in the wear of ion-implanted steels”, 04/01/07, 2003, scientific advisor Yu.P. Sharkeev.

2. Shashkina Galina Alekseevna, candidate of technical sciences. Dissertation “Production of calcium phosphate coating using the micro-arc method. Structure and properties of titanium-based biocomposite with calcium phosphate coating,” 05.17.11; 04/01/07, 2006, scientific supervisor Sharkeev Yu.P.

3. Fortuna Sergey Valerievich, candidate of technical sciences. Dissertation “Microstructure of titanium nitride-based coatings obtained by vacuum methods”, 04/01/07, 2006, scientific advisor, Sharkeev Yu.P.

4. Eroshenko Anna Yurievna, candidate of technical sciences. Dissertation “Improving the method of severe plastic deformation for obtaining high-strength titanium blanks VT1-0 in submicrocrystalline and nanostructural states for medical use”, 05.16.01, 2010, scientific advisor Yu.P. Sharkeev.

5. Bozhko Irina Aleksandrovna, candidate of physical and mathematical sciences. Dissertation “Patterns of formation of ultradisperse intermetallic phases in the surface layers of nickel and titanium during high-intensity ion implantation”, 04/01/07, 2008, scientific advisor Yu.P. Sharkeev.

6. Kulyashova Ksenia Sergeevna, candidate of technical sciences. Dissertation “Patterns of formation of micro-arc calcium phosphate bio-coatings on the surface of zirconium and their properties”, 04/01/07, 2011, scientific advisor Yu.P. Sharkeev.

7. Legostaeva Elena Viktorovna, Doctor of Technical Sciences. Dissertation “Patterns of formation of the structure and properties of calcium phosphate coatings on the surface of bioinert titanium and zirconium alloys”, 04/01/07, 2014, scientific consultant Sharkeev Yu.P.

8. Komarova Ekaterina Gennadievna, candidate of technical sciences. Dissertation “Patterns of formation of the structure and properties of micro-arc coatings based on substituted hydroxyapatites on titanium and niobium alloys”, 04/01/07, 2017, scientific advisor Yu.P. Sharkeev.

9. Khimich Margarita Andreevna, candidate of technical sciences. Dissertation “Physical basis of the formation of the structure and phase composition of the Ti-(40-45) wt. alloy. % by the method of selective laser fusion”, 04/01/07, 2020, scientific supervisor Sharkeev Yu.P.

10. Chebodaeva Valentina Vadimovna, candidate of technical sciences. Dissertation “Modification of the structure and charge state of micro-arc calcium phosphate coatings by introducing AlO(OH) and ZnO nanoparticles to improve functional properties”, 04/01/07, 2021, scientific advisor Yu.P. Sharkeev.

11. Prosolov Konstantin Aleksandrovich, candidate of physical and mathematical sciences. Dissertation “Physical factors in the formation of bioactive and antibacterial calcium phosphate coatings using high-frequency magnetron sputtering”, 1.3.8. (01.04.07), 2021, scientific supervisor Sharkeev Yu.P.