Laboratory of Nanobioengineering

Laboratory of Nanobioengineering


Alexander Sergeevich

Doctor of Technical Sciences
Tel.: (382-2) 28-68-25

More details

Brief historical background about the unit

The laboratory was organized in 2018. The main scientific team of the laboratory is represented by members of the youth group formed in 2014. Psakhye S.G. to carry out scientific projects within the framework of medical materials science.

Areas of research, directions of fundamental research

Obtaining new knowledge in the field of interaction of nanostructured materials with biological objects for the development of biomedical materials with targeted action, including for medical diagnostic systems; biofiltration membrane materials; nanomaterials for drug delivery; antitumor and antimicrobial nanomaterials, including those that potentiate the effect of drugs.

Problems solved within these areas

1. Development of methods for suppressing the proliferation of tumor cells in in vitro experiments by changing the acidity of their microenvironment using nanostructured metal oxides.

2. Development of the scientific basis for overcoming bacterial resistance to antibiotics using nanostructured materials.

3. Development of methods for modifying surfaces to ensure targeted interaction with biological objects.

4. Design of new antimicrobial agents.

Unit composition

The total number of people is 13, including: 1 Doctor of Science, 4 Candidates of Science, 7 graduate students, 9 young researchers (up to 33 years old).

List of staff members

1. Lozhkomoev Alexander Sergeevich, head of laboratory, Doctor of Technical Sciences,

2. Olga Vladimirovna Bakina, senior researcher, doctor of technical sciences,

3. Kazantsev Sergey Olegovich, junior researcher,

4. Toropkov Nikita Evgenievich, junior researcher,

5. Suliz Konstantin Vladimirovich, junior researcher,

6. Chebodaeva Valentina Vadimovna, junior researcher, candidate of technical sciences,

7. Khimich Margarita Andreevna, junior researcher, candidate of technical sciences,

8. Prosolov Konstantin Aleksandrovich, junior researcher,

9. Buyakov Ales Sergeevich, junior researcher, Ph.D.

10. Akkuzin Sergey Aleksandrovich, junior researcher,

11. Buslovich Dmitry Gennadievich, junior researcher,

12. Vornakova Ekaterina Andreevna, postgraduate student of the Institute of Physics and Mathematics of Applied Mathematics SB RAS, laboratory assistant,

13. Zhou Valeria Romanovna, postgraduate student of the Institute of Physics and Mathematics of Applied Mathematics SB RAS, laboratory assistant,

The most important scientific results

Methods have been developed for the synthesis of nanostructured metal oxides that can suppress bacterial resistance to antibiotics.

New antimicrobial agents based on multicomponent nanoparticles have been developed.

Methods have been developed for producing porous nanoparticles that are promising for drug delivery.

Projects, grants agreements

State assignment projects:

III.23.2.10. Scientific basis for the development of nanostructured materials that potentiate the effect of drugs and the development of methods and approaches of highly informative infrared and terahertz spectroscopy for analyzing the composition of various media, including biological ones

FWRW-2021-0007. Scientific basis for the creation of functional coatings and bulk nanostructured materials for biomedical purposes using additive technologies, compositions of heterophasic nanoparticles with polymers and bulk nanocrystalline pseudoalloys

RSF projects:

No. 17-19-01319 “Promising nanostructured alloys formed by compacting bimetallic nanoparticles from immiscible metals: preparation, structure, physical and mechanical properties.”

No. 17-79-20382 "Design of new antimicrobial agents based on bicomponent metal nanoparticles and their oxides."

No. 21-73-10265 "Development of polymer-modified 3D porous calcium phosphate structures on the surface of titanium implants as a delivery system for biologically active substances, assessment of their effect on cellular activity using laser interference microscopy"

Federal Targeted Program projects:

No. 14.604.21.0156 “Development of nanomaterials based on Al and Fe oxides and hydroxides, providing targeted ionic modification of biological media and potentiation of the action of drugs, and the creation on their basis of effective hemostatic agents with an antimicrobial effect.”

Major publications

1. Lerner, M. I., Mikhaylov, G., Tsukanov, A. A., Lozhkomoev, A. S., Gutmanas, E., Gotman, I., ... & Vasiljeva, O. (2018). Crumpled Aluminum Hydroxide Nanostructures as a Microenvironment Dysregulation Agent for Cancer Treatment //Nano Letters. - 2018. - T. 18. - No. 9. - pp. 5401-5410.

2. Lerner, M. I., Psakhie, S. G., Lozhkomoev, A. S., Sharipova, A. F., Pervikov, A. V., Gotman, I., & Gutmanas, E. E. (2018). Fe-Cu Nanocomposites by High Pressure Consolidation of Powders prepared by Electric Explosion of Wires //Advanced Engineering Materials. - 2018. - P. 1701024.

3. Lozhkomoev AS et al. On the possibility of soft matter nanostructure formation based on mesoporous aluminum hydroxide. Prospects for biomedical applications //Physical Mesomechanics. - 2017. - T. 20. - No. 2. - pp. 134-141.

4. Lozhkomoev AS Kazantsev SO, Glazkova EA, Bakina OV, Kondranova AM, Svarovskaya NV, Rodkevich NG, Lerner MI Synthesis, characterization and properties of porous micro/nanostructures obtained by oxidizing aluminum nanoparticles with water in the presence of glass fibers //Materials Research Express. - 2018. - T. 5. - No. 11. - P. 115011.

5. Kazantsev SO, Lozhkomoev AS, Glazkova EA, Gotman I., Gutmanas EY, Lerner MI, Psakhie SG. Preparation of aluminum hydroxide and oxide nanostructures with controllable morphology by wet oxidation of AlN/Al nanoparticles //Materials Research Bulletin. - 2018. - T. 104. - P. 97-103.

6. Lozhkomoev AS, Pervikov AV, Bakina OV, Kazantsev SO, Gotman I. Synthesis of antimicrobial AlOOH-Ag composite nanostructures by water oxidation of bimetallic Al-Ag nanoparticles // RSC Advances. - 2018. - T. 8. - No. 63. - pp. 36239-36244.

7. Lerner MI et al. Synthesis of Al nanoparticles and Al/AlN composite nanoparticles by electrical explosion of aluminum wires in argon and nitrogen //Powder Technology. - 2016. - T. 295. - P. 307-314.

8. Lozhkomoev AS et al. Synthesis of core-shell AlOOH hollow nanospheres by reacting Al nanoparticles with water //Nanotechnology. - 2016. - T. 27. - No. 20. - S. 205603.

9. Lerner MI et al. Structures of binary metallic nanoparticles produced by electrical explosion of two wires from immiscible elements //Powder Technology. - 2016. - T. 288. - P. 371-378.

10. Bakina OV et al. Cellulose acetate fibers surface modified with AlOOH/Cu particles: synthesis, characterization and antimicrobial activity //Cellulose. - 2018. - T. 25. - No. 8. - pp. 4487-4497.

11. Fomenko A. et al. Influence of Morphology and Textural Characteristics of Оі-Al 2 O 3 Nanostructures on the Potentiation of Doxorubicin // Journal of Cluster Science. - 2021. - pp. 1-7.

12. Pervikov AV et al. Bimetallic AlAg, AlCu and AlZn nanoparticles with controllable phase compositions prepared by the electrical explosion of two wires //Powder Technology. - 2020. - T. 372. - P. 136-147.

13. Bakina OV et al. Synthesis and antibacterial activity of cellulose acetate sheets modified with flower-shaped AlOOH/Ag //Cellulose. - 2020. - T. 27. - P. 6663-6676.